Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes
نویسندگان
چکیده
منابع مشابه
Reprogramming into pancreatic endocrine cells based on developmental cues.
Due to the increasing prevalence of type 1 diabetes and the complications arising from actual therapies, alternative treatments need to be established. In order to compensate the beta-cell deficiency associated with type 1 diabetes, current researches focus on new strategies to generate insulin-producing beta cells for transplantation purpose, including the differentiation of stem or progenitor...
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Pdx1 (pancreatic and duodenal homeobox 1), Ngn3 (neurogenin 3) and MafA (v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A) have been reported to bring about the transdifferentiation of pancreatic exocrine cells to beta (β) cells in vivo. We have investigated the mechanism of this process using a standard in vitro model of pancreatic exocrine cells, the rat AR42j-B13 cell line. W...
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ژورنال
عنوان ژورنال: Current Pathobiology Reports
سال: 2015
ISSN: 2167-485X
DOI: 10.1007/s40139-015-0068-0